Akio Otsuka

Old Snake (voice)

David Hayter

Old Snake (English voice)

Hideyuki Tanaka

Hal "Otacon" Emmerich / Jonathan (voice)

Christopher Randolph

Hal "Otacon" Emmerich (English voice)

Kikuko Inoue

Sunny / Rosemary (voice)

Cristina Pucelli

Sunny (English voice)

Takeshi Aono

Roy Campbell (voice)

Paul Eiding

Roy Campbell (English voice)

Keiji Fujiwara

Drebin (voice)

Khary Payton

Drebin (English voice)

Kyoko Terase

Meryl Silverburgh (voice)

Debi Mae West

Meryl Silverburgh (English voice)

Jun Fukuyama

Johnny "Akiba" (voice)

Beng Spies

Johnny "Akiba" (English voice)

Kenyu Horiuchi

Raiden (voice)

Quinton Flynn

Raiden (English voice)

Houko Kuwashima

Mei Ling (voice)

Kim Mai Guest

Mei Ling (English voice)

James Sie

Jonathan (English voice)

Shozo Iizuka

Ed (voice)

Dave Fennoy

Ed (English voice)

Lara Cody

Rosemary (English voice)

Yūya Kawamura

Little John (voice)

Jennifer Hale

Little John (English voice)

Chikao Ohtsuka

Big Boss (voice)

Richard Doyle

Big Boss (English voice)

Colleen O'Shaughnessey

Local Boy (voice)