Jean Dujardin

Lucky Luke

Melvil Poupaud

Jesse James

Sylvie Testud

Calamity Jane

Alexandra Lamy

Belle

Michaël Youn

Billy The Kid

Daniel Prévost

Pat Poker

Chloé Jouannet

Eleanor

Jean-François Balmer

Le gouverneur

André Oumansky

President

Gabriel Corrado

Luke's Father

Pompeyo Audivert

Undertaker

Atilio Pozzobón

Barman

Alberto Laiseca

Dick Digger

Mathias Sandor

Young Luke

Carolina Presno

Luke's Mother

Carlos Kaspar

Hank

Mirta Wons

Mrs. Flimsey

Jorge Noya

Mr. Flimsey

Claudio Weppler

Phil Defer

Horacio Marassi

Colonel Mc Straggle

Daniel Campomenosi

Dr. Doxey

Kazuomi Takagi

Ming Li Fu

Luciano Cáceres

Henchman

Joaquín Berthold

Henchman

Martín Kohan

Henchman

Óscar Kramer

Politician

Daniela Catz

Saloon Girl

Bruno Salomone

Jolly Jumper (voice)